Drahomíra Matznerová Chvátalová studied at the Prague Conservatory under the tutelage of Professor Jan Hora and at the Academy of Performance in the studio of Professor Jaroslav Tůma. At the time of her studies, she participated in numerous organ courses in the Czech Republic, the Netherlands, and France under the leadership of Petr Eben, Martin Sander, Heidi Emmert, Jan Jongepier, and Jan Willem Janssen. As a student, she won 3rd prize at the Petr Eben Organ Competition, and at the Moravian Autumn international music competition she advanced to the semifinals.

The bulk of her repertoire consists of romantic and modern music, with a special emphasis on French organ literature of the 19th and 20th centuries. For Czech Radio, she has recorded premieres of works by the leading Czech composers Jiří Ropek, Jiří Laburda, Jan Bernátek, Karel Sklenička and Emil Viklický.

As a soloist, she performs in concert regularly in the Czech Republic and abroad. She has appeared at such festivals as the St. Wenceslas Festivities, Days of Contemporary Music, Tanvald Musical Spring, and the Český Krumlov Chamber Music Festival. In the autumn of 2009 she performed the Concerto for Organ and Orchestra by Francis Poulenc at the closing concert of the Malá Strana Chamber Festivities. In 2010 she gave a solo recital at the Prague Spring International Music Festival, and that same year she performed at the Kutná Hora International Music Festival and organ festival at the St. Vitus Cathedral in Prague. In 2012 at the PROMS festival, together with the trumpet soloist Jan Hasenöhrl she gave the world premiere of Emil Viklický’s composition Variations on Over The Rainbow. Wherever she has appeared on stage, she has been highly regarded by music critics. In the coming season, she will be appearing as a soloist with the Prague Symphony Orchestra at Smetana Hall in Prague in the Concerto for Organ and Orchestra by Petr Eben.

Drahomíra Matznerová is also in demand as a performer of chamber music, collaborating with leading vocal and instrumental soloists. In addition to playing in chamber music and as a soloist, she works continuously with various ensembles performing the oratorio repertoire.

Since 1995, she has held the position of organist at the Church of Our Lady Victorious in Prague – Malá Strana, where she played for Pope Benedict XVI at his visit to the Infant Jesus of Prague. Additionally, since 1996, she has been the organist for ceremonies held at New Town Hall.